Fibromyalgia — The recommended dose for Cymbalta is 60 mg administered once daily. Treatment should begin at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. The efficacy of CYMBALTA in the treatment of generalized anxiety disorder (GAD) was established in 1 fixed-dose randomized, double-blind, placebo-controlled trial and 2 flexible-dose randomized, double-blind, placebo-controlled trials in adult outpatients between 18 and 83 years of age meeting the DSM-IV criteria for GAD. Cymbalta (duloxetine) is an antidepressant that treats depression and anxiety. It can also treat pain-related conditions such as fibromyalgia, chronic muscle pain, and diabetic neuropathy (nerve pain). The recommended Cymbalta dosage typically starts at 30 mg daily. It’s often raised to 60 mg once daily after 1 to 2 weeks. Cymbalta dosages of up to 120 mg daily are sometimes needed for. Cymbalta is used to treat depression and certain other conditions. Find out what the recommended dosages are, how to take the drug, and more. Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). The maximum dosage of Cymbalta for anxiety and depression is 120 milligrams (mg), taken once per day. The maximum dosage for chronic pain, fibromyalgia and pain due to diabetic neuropathy is 60 mg. The recommended starting CYMBALTA dosage in pediatric patients 13-17 years of age with fibromyalgia is 30 mg once daily. The dosage may be increased to 60 mg once daily based on response and tolerability. Detailed dosage guidelines and administration information for Cymbalta (duloxetine hydrochloride). Includes dose adjustments, warnings and precautions. Cymbalta is a prescription medicine used to treat symptoms of major depressive disorder, diabetic peripheral neuropathic pain, generalized anxiety disorder, fibromyalgia, and chronic muscle pain. Learn about dosage, side effects, drug interactions, warnings, and others. Medscape - Generalized anxiety disorder, major depressive disorder, fibromyalgia-specific dosing for Cymbalta, Drizalma Sprinkle (duloxetine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.